张延东

发布日期:2018-03-22     浏览次数:次   

课题组长,教授,博士生导师
电话:(0592)2181902
传真:(0592)2181902
电子邮箱: ydzhang@xmu.edu.cn  
课题组主页: http://zhanglab.xmu.edu.cn/

个人简历:

教授(厦门大学,2017年8月至今)
副教授(厦门大学, 2011年1月-2017年7月)
博士后研究员 (美国哥伦比亚大学,2008-2010, Danishefsky教授)
博士(北京大学,2004-2008,杨震教授)
硕士(北京大学,1999-2002,陈家华教授)
学士(北京理工大学和中科院化学所,1994-1998,江英彦教授)

荣誉与获奖:

田昭武学科交叉奖(2021),祥华特聘教授(2020),建行奖教金(2018),福建省高校新世纪优秀人才支持计划(2016),金达威特聘教授(2015),清源奖教金(2014),金达威一等奖教金(2012),杜邦奖学金(2006) ,罗氏创新化学奖(2006),光华奖学金(2001)


主讲课程:
本科生:《有机化学一》,《有机化学二》,《有机化学研讨课一》,《有机化学研讨课二》,《有机化学新兴领域简介》,《化学基础I》、《合成化学I》;

研究生:《化学研究前沿之有机化学》

担任职务:有机化学研究所所长,有机化学课程组组长

 

研究兴趣:

碳氢官能化促进的活性天然产物全合成、海洋药物化学、天然产物化学生物学

近期主要代表论著:


  1. 01. Cui, H.+; Shen, Y.+; Chen, Y.; Wang, R.; Wei, H.; Fu, P.; Lei, X.; Wang, H.; Bi, R.; Zhang, Y.* Two-Stage Syntheses of Clionastatins A and B. J. Am. Chem. Soc. 2022, 144, 8938–8944.

  2. 02. Shen, Y.+; Li, L.+; Xiao, X.+; Yang, S.; Hua, Y.; Wang, Y.; Zhang, Y.-w.;* Zhang, Y.* Site-Specific Photochemical Desaturation Enables Divergent Syntheses of Illicium Sesquiterpenes. J. Am. Chem. Soc. 2021, 143, 3256–3263.

  3. 03. Jiang, X.+; Zeng, Z.+; Hua, Y.+; Xu, B.; Shen, Y.; Xiong, J.; Qiu, H.; Wu, Y.; Hu, T.;* Zhang, Y.* Merging C–H Vinylation with Switchable 6π-Electrocyclizations for Divergent Heterocycle Synthesis. J. Am. Chem. Soc. 2020, 142, 15585–15594.

  4. 04. Chen, R.+; Zhang, F.+; Hua, Y.+; Shi, D.; Lei, X.; Xiao, H.; Wang, Y.; Zhang, Y.* Total Synthesis of Stemarene and Betaerene Diterpenoids: Divergent Ring-Formation Strategy and Late-Stage C−H Functionalization. CCS Chem. 2022, 4, 987–995.

  5. 05. Chen, R.; Shen, Y.; Yang, S.; Zhang, Y.* Conformational Design Principles in Total Synthesis. Angew. Chem. Int. Ed. 2020, 59, 14198–14210.

  6. 06. Xu, B.+; Jiang, X.+; Xiong, J.; Lan, J.; Tian, Y.; Zhong, L.; Wang, X.; Xu, N.; Cao, H.; Zhang, W.; Zhang, H.; Hong, X.; Zhan, Y.-y.;* Zhang, Y.;* Hu, T.* Structure-Activity Relationship Study Enables the Discovery of a Novel Berberine Analogue as RXRα Activator to Inhibit Colon Cancer. J. Med. Chem. 2020, 63, 5841–5855.

  7. 07. Liu, C.+; Chen, R.+; Shen, Y.; Liang, Z.; Hua, Y.; Zhang, Y.* Total Synthesis of Aplydactone by a Conformationally Controlled C−H Functionalization. Angew. Chem. Int. Ed. 2017, 56, 8187–8190.

  8. 08. Li, J.; Zhao, H.; Jiang, X.; Wang, X.; Hu, H.; Yu, L.; Zhang, Y.* The Cyano Group as a Traceless Activation Group for the Intermolecular [3+2] Cycloaddition of Azomethine Ylides: A Five-Step Synthesis of (±)-Isoretronecanol. Angew. Chem. Int. Ed. 2015, 54, 6306–6310.

  9. 09. Zhang, F.; Niu, Y.; Hong, D.; Ye, Y.; Hua, Y.; Ding, S.; Zhang, Y.* Synthetic Studies towards Atkamine. Chin. Chem. Lett. 2021, 32, 668–671.

  10. 10. Zeng, Z.; Zhao Y.; Zhang, Y.* Divergent total syntheses of five illudalane sesquiterpenes and assignment of the absolute configuration. Chem. Commun. 2019, 55, 4250–4253.

  11. 11. Chen, R.; Li, L.; Lin, N.; Zhou, R.; Hua, Y.; Deng, H.; Zhang, Y.* Asymmetric Total Synthesis of (+)-Majusculoic Acid via a Dimerization–Dedimerization Strategy and Absolute Configuration Assignment. Org. Lett. 2018, 20, 1477–1480.

  12. 12. Lin, M.; Cai, P.-J.; Zeng, Z.; Lin, N.; Shen, Y.; Tang, B.; Li, F.; Chen, C.; Yu, Z.-X.;* Zhang, Y.* Conformational Bias by a Removable Silyl Group: Construction of Bicyclo[n.3.1]alkenes by Ring Closing Metathesis. Chem. Eur. J. 2018, 24, 2334–2338.

  13. 13. Jiang, X.+; Zeng, Z.+; Shi, D.; Liu, C.; Zhang, Y.* Divergent total syntheses of pseudoberberine and nitidine through C–H vinylation and switchable 6π electrocyclizations. Tetrahedron Lett. 2021, 66, 152839.

  14. 14. Chen, R.; Yang, S.; Zhang, Y.* Recent progress in the total synthesis of marine brominated sesquiterpene aplydactone. Org. Biomol. Chem. 2020, 18, 1036–1045.

  15. 15. Lin, M.; Cui, H.; Hua, Y.; Zhang, Y.* Domino enyne metathesis en route to skeletally diverse, privileged scaffolds: synthesis of the tricyclic core of pseudolaric acid F. Org. Chem. Front. 2019, 6, 2771–2774.

  16. 16. Zeng, Z.; Chen, C.; Zhang, Y.* Enantioselective total synthesis of periconiasin A. Org. Chem. Front. 2018, 5, 838–840.

  17. 17. Li, J.; Ye, Y.; Zhang, Y.* Cycloaddition/annulation strategies for the construction of multisubstituted pyrrolidines and their applications in natural product synthesis. Org. Chem. Front. 2018, 5, 864–892.

  18. 18. Liu, C.; Zeng, Z.; Chen, R.; Jiang, X.; Wang, Y.; Zhang, Y.* Total Synthesis of (+)-Fusarisetin A Driven by a One-Pot Four-Reaction Process. Org. Lett. 2016, 18, 624-627.

  19. 19. Li, L.; Shen, Y.; Zhang, Y.* Synthetic Progress of Jiadifenolide. Chin. J. Org. Chem. 2016, 36, 439–446.

  20. 20. Shen, Y.; Li, L.; Pan, Z.; Wang, Y.; Li, J.; Wang, K.; Wang, X.; Zhang, Y.; Hu, T.; Zhang, Y.* Protecting-Group-Free Total Synthesis of (±)-Jiadifenolide: Development of a [4 + 1] Annulation toward Multisubstituted Tetrahydrofurans. Org. Lett. 2015, 17, 5480–5483.


研究思路:



 

 



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